Two of the troopers were killed on Saturday, one in a Taliban attack and the other in a roadside bomb attack, NATO said without providing more details.
The other two died on Sunday in a traffic accident.
Two foreign soldiers and two civilians were killed in a car accident in Afghanistan's southern Kandahar province on Sunday, provincial officials said.
The accident occurred on Kandahar Airport Ave when a Nato supply truck hit a military vehicle, killing two foreign soldiers and two Afghan drivers, provincial spokesman Jawid Faisal said.
The International Security Assistance Force confirmed the deaths.
Meanwhile, in a separate incident on Saturday, a US-led helicopter made a forced landing in south Afghanistan, the coalition forces said.
It came only a day after Australia's Department of Defence said one of its CH-47 Chinook helicopters was damaged in a hard landing during combat support operations in Kandahar province on Friday.
According to the independent website icasualties.org, the latest deaths brought to 3056 the number of the US-led foreign troopers killed in Afghanistan since the US-led invasion of the country in 2001.
In another incident the Baraki Barak district of Logar province police chief was killed along with his two guards during Taliban attack, officials said on Saturday.
Meanwhile, an Afghan local police (ALP) officer opened fire on his fellow policemen on Friday, killing at least one and wounding three others, local officials said.
A Taliban spokesman Qari Yousuf Ahmadi claimed responsibility for the attack saying that the infiltrator was a member of the hardline militant group.
The attacker fled the scene immediately after the incident which happened in the Char Chino district of southwestern Uruzgan province, and has not been apprehended.